Substance

Rasagiline

Brand name:
Azilect

Description

 
Antidepressant
 
Azilect can be used as a monopreparation or in combination with other antiparkinsonian drugs
Brands:
Azilect
Availability:
Prescription needed
Pregnancy:
Consult a doctor
Alcohol:
It is not worth combining
Side Effects:
Shivering, Trouble Concentrating, Hair Loss
Interactions:
Ropinirole, Clonazepam, Sinemet CR (carbidopa / Levodopa)
For informational purposes only. Consult your local medical authority for advice.

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Daybue is supplied as a strawberry-flavored oral solution containing 200 mg of trofinetide per mL. The product, which received FDA approval in March 2023, was approved based on data from the randomized, double-blind, placebo-controlled phase 3 LAVENDER study (ClinicalTrials. The dosage is determined by patient weight and can be administered orally or via gastrostomy tube azilect package insert.

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The dosage is determined by patient weight and azilect package insert can be administered orally or via gastrostomy tube. The most common adverse reactions reported with trofinetide led to statistically significant improvements on the Rett Syndrome Behaviour Questionnaire total score and the Clinical Global Impression-Improvement score at week 12 compared with placebo (coprimary endpoints). The most common adverse reactions reported with trofinetide were diarrhea and vomiting.

I am thrilled to now be able to offer Daybue to more people living with Rett syndrome, outside of a clinical trial.

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What should I tell my health care providers before I take Azilect?

You should not take rasagiline if you are allergic to it. Many medicines can interact with rasagiline and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • cyclobenzaprine (a muscle relaxer);

  • dextromethorphan (contained in many over-the-counter cough medicines);

  • meperidine (Demerol);

  • methadone;

  • St. John's wort; or

  • tramadol (Ultram, Ultracet).

Do not use rasagiline if you have used any other MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, selegiline, tranylcypromine, and others. To make sure rasagiline is safe for you, tell your doctor if you have:

  • high or low blood pressure;

  • liver disease;

  • if you take an antidepressant; or

  • if you take ciprofloxacin (an antibiotic).

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether rasagiline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Azilect. It is not known whether rasagiline passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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